張德凱 主任醫(yī)師
教授、博士生導(dǎo)師，現(xiàn)任哈醫(yī)大二院消化內(nèi)科主任。
中國醫(yī)學(xué)會腫瘤精準(zhǔn)治療專業(yè)委員會委員
中國醫(yī)師協(xié)會整合腫瘤學(xué)專業(yè)委員會委員
1983年考取哈爾濱醫(yī)科大學(xué)醫(yī)療專業(yè)
1988年畢業(yè)后留在哈醫(yī)大二院消化內(nèi)科工作
1990年考取哈醫(yī)大二院消化內(nèi)科張安田教授在職碩士研究生
1993年畢業(yè)后繼續(xù)留在哈醫(yī)大二院消化內(nèi)科工作
1995年考取香港大學(xué)醫(yī)學(xué)院腫瘤細(xì)胞學(xué)George SW Tsao教授博士研究生
1998年在耶魯大學(xué)醫(yī)學(xué)院腫瘤藥理學(xué)和免疫學(xué)教研室做博士后研究
2005年在休斯敦德州醫(yī)學(xué)中心作為首席科學(xué)家（PI）建立實(shí)驗(yàn)室。并一直從事消化系統(tǒng)疾病免疫與炎癥方面的科研工作 ，掌握最新的科學(xué)研究發(fā)展趨勢。所從事的科研工作具有潛在的轉(zhuǎn)化前景，期望研發(fā)出靶向作用于免疫受體的新的抗感染，抗炎癥，及抗腫瘤藥物。
Most Significant 10 Publications (out of about 60 peer-reviewed papers, *correspondence)
Zhang D., Zhang GL, Hayden MS, Greenblatt M, Bussey C., Flavell R., and Ghosh S. A novel Toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5; 303(5663):1522-6. (2015 影響因子(IF): 34.66; Google Scholar Citation: 1151)
Hot Paper of the Year in Immunology
(Highly cited) www.esi-topics.com/nhp/2005/may-05-Ghosh_Hayden_Zhang.html
Yarovinsky F., Zhang D., Andersen J., Bannenberg GL., Serhan C., Hieny S., Flavell RA., Ghosh S., Sher A. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005 Jun 10; 308(5728):1626-9. (IF: 34.66; Google Scholar Citation: 855)
Rao P, Hayden M, Long M, Scott M, West P, Zhang D, Lynch C, Hoffman A, Baltimore D, Oeckinghaus A, Ghosh S. IκBβ acts to both inhibit and activate gene expression at different stages of the inflammatory response. Nature 2010 466(7310):1115-9. PMID: 20740013. (IF: 38.14)
Cai Z, Sanchez A, Shi Z, Zhang T, Zhang D.* Activation of Toll-Like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth. Cancer Res. 2011 Apr 1;71(7):2466-75. PMID: 21427357. (IF: 8.56)
Shi Z, Cai Z, Zhang T, Zhao S, Smeds E, Zhang Q, Wang F, Fu S, Ghosh S, Zhang D*. TLR11 Prevents Salmonella’s penetration into the murine Peyer’s Patches, J Biol Chem 2012.
Mathur R, Oh H, Zhang D, Park SG, Seo J, Koblansky A, Hayden MS, Ghosh S. A mouse model of salmonella typhi infection. Cell. 2012 Oct 26;151(3):590-602. PMID: 23101627. (IF: 28.71)
Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, Zhang H, An L, Zhao Y, Chen Z, Kogiso M, Zhang D, Zhang H, Zhang P, Jung JU, Li X, Xu G, Yang J. USP21 negatively regulates antiviral response by acting as
